Regional and kinetic changes in gut permeability and the mechanisms of transport across the piglet gut wall

猪（母猪）的子宫不与胎儿共享循环。因此，仔猪出生时免疫幼稚。他们必须摄入初乳以获得被动免疫力，否则他们将死于传染病。据报道，仔猪肠道在出生后的前两天是半渗透性的，以促进初乳来源的细胞和大分子（即抗体、细胞因子、抗微生物肽等）的摄取。在这短暂的一段时间后，肠道经历了一个成熟过程，使其不再是半渗透性的。我们打算了解发生在仔猪肠道从半渗透到“封闭”状态的转变过程中的基本生理和生物变化。

The uterus of a pig (sow) does not share circulation with the fetus. Therefore piglets are born immunologically naïve. They must ingest colostrum to receive passive immunity or they will die from infectious diseases. The piglet gut is reported to be semi-permeable for the first two days after birth to facilitate uptake of colostrum-derived cells and macromolecules (i.e. antibodies, cytokines, antimicrobial peptides, etc.). After this brief period of time, the gut undergoes a maturation process so that it is no longer semi-permeable. We intend to understand the basic physiological and biological changes that take place in the piglet gut during the transition from a semi-permeable to a 'closed' state.