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Investigation of the role of HIV-Envelope specific antibody dependent innate immune cell functionality in HIV control.

Investigation of the role of HIV-Envelope specific antibody dependent innate immune cell functionality in HIV control.
研究 HIV 包膜特异性抗体依赖性先天免疫细胞功能在 HIV 控制中的作用。
批准号：
343839
负责人：
Bernard Nicole F
金额：
$55.69万
依托单位：
Research Institute of the McGill University Health Centre
依托单位国家：
加拿大
项目类别：
Operating Grants
财政年份：
2016
资助国家：
加拿大
项目状态：
已结题
起止时间：
2016-03-01 至 2021-03-01
来源：
https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=343839&lang=en
关键词：
Acute Infection Antibodies Antibody Dependent Functions Complement Elite Controllers Hiv/Aids Immune Correlates Of Hiv Control Innate Immunity Monocytes Nk Cells

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中文摘要
翻译
抗体（Ab）分子具有特异性结合抗原的Fab区和结合许多类型的先天免疫细胞上的各种Fc受体（FcR）的Fc区。Fc-FcR相互作用可以激活FcR+先天免疫细胞并诱导抗病毒免疫。
英文摘要
Antibody (Ab) molecules have an Fab region, which binds antigen specifically and an Fc region, which binds to various Fc receptors (FcR) on many types of innate immune cells. Fc-FcR interactions can activate FcR+ innate immune cells and induce anti-viral
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会议论文
Close encounters of a Natural Killer kind: Understanding how NK cells protect against HIV infection.
Close encounters of a Natural Killer kind: Understanding how NK cells protect against HIV infection.
Determinants of the functional cure profile observed in HIV infected Elite Controllers.
Natural Killer (NK) cell mediated anti-viral activity in HIV infected slow progressors: Killer Immunoglobulin like receptor (KIR)/HLA genotype as a determinant of NK function.
海外基金