Graphite calorimeter probe for clinical radiation dosimetry

这项从想法到创新的提案建立在正在申请专利的探针热量计技术的基础上，采取重大步骤，将一种革命性的新型自校准辐射剂量计系统推向市场。本系统可用于放射治疗单位放射治疗癌症的医学应用以及涉及电离辐射剂量精确测量的其他应用中，用于临床参考剂量的测定。该提案旨在改进探测器系统的设计和制造质量，将让该系统接受第三方验证，并将为建立和合并一家名为Caldose的初创公司提供基础。Caldose将是第一家为放射治疗诊所、剂量校准实验室以及其他辐照设施（食品加工、核医学、放射生物学、医疗灭菌、安全服务等）提供自校准剂量测定系统的公司。由于目前的剂量测量系统依赖于从初级标准剂量实验室获得的校准系数，因此它们的准确使用仅限于一组特定的标准条件。任何偏离这些校准条件（例如，实际患者设置）的这些设备的使用都必须正确计算，这通常导致测量剂量的显着不确定性。我们正在申请专利的技术是基于过去60年来由标准剂量学实验室建立的量热学概念，并提供在护理点测量输送剂量的最直接方法。

This Idea-to-Innovation proposal builds on patent-pending probe calorimeter-based technology to take significant steps to bring to market a revolutionary new, self-calibrating radiation dosimeter system. This system is useful in clinical reference determination of delivered dose in the medical application of radiation to the treatment of cancer of radiation therapy units as well as in other applications involving the accurate measurement of ionizing radiation dose. The proposal aims to refine the design and manufacturing quality of the detector system, will have the system undergo third-party validation and will provide a foundation to establish and incorporate a start-up company, called Caldose. Caldose will be the first company to make available a self-calibrating dosimetry system for applications in radiation therapy clinics, dose calibration laboratories, as well as other irradiation facilities (food processing, nuclear medicine, radiobiology, medical sterilization, security services, etc.). Since current dose measurement systems rely on calibration coefficients obtained from a primary standards dose laboratory, their accurate use is limited to a particular set of standard conditions. Any use of these devices that deviates from these calibration conditions (e.g., a realistic patient setup) must be correctly accounted, which often leads to significant uncertainty on the measured dose. Our patent-pending technology is based on calorimetric concepts that have been established over the last 60 years by standards dosimetry labs, and offers the most direct means of measuring the delivered dose at the point of care.