Characterizing the roles of RIF1 and 53BP1 in DNA double strand break repair pathways in the context of PARP1 inhibition
Characterizing the roles of RIF1 and 53BP1 in DNA double strand break repair pathways in the context of PARP1 inhibition
批准号:
361556
负责人:
Setiaputra Dheva T
金额:
$9.83万
依托单位国家:
加拿大
项目类别:
Fellowship Programs
财政年份:
2016
资助国家:
加拿大
项目状态:
已结题
起止时间:
2016-11-01 至 2019-11-01
中文摘要
携带BRCA1基因突变的女性患乳腺癌的几率超过50%。最近一类化疗药物,聚ADP核糖聚合酶1 (PARP1)抑制剂,在brca1突变的乳腺癌中显示出有希望的结果。然而,一些
英文摘要
Women carrying mutations in the BRCA1 gene has over 50% chance of developing breast cancer. A recent class of chemotherapeutics, poly ADP ribose polymerase 1 (PARP1) inhibitors, has shown promising results in BRCA1-mutated breast cancer. However, several
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