Proteomic investigation of alternative splicing in the control of cell differentiation

选择性剪接在真核生物中产生蛋白质组多样性中起着重要作用，因为初级信使（前mRNA）在此过程中通过包含和排除特定的蛋白质编码外显子组而转变为多个成熟信使。选择性剪接是多种生物过程中细胞分化所必需的。尽管其重要性，在细胞分化过程中控制选择性剪接的精确机制仍然知之甚少。

Alternative splicing plays an important role in generating proteome diversity in eukaryotes, as primary messengers (pre-mRNA) turn into multiple mature messengers by inclusion and exclusion of specific sets of protein-coding exons during the process. Alternative splicing is required for cell differentiation in a wide range of biological processes. Despite its importance, the precise mechanisms controlling alternative splicing during cell differentiation remain poorly understood.