Epithelial tissue morphogenesis in metazoans

由上皮细胞组成的上皮细胞界定了复杂生物体外部环境和内部之间的边界。因此，上皮细胞覆盖身体的表面（例如皮肤），并在器官的内腔（在肠，肺，肝等中发现）中排列。上皮细胞的一个重要功能是选择性地运输分子，例如从肠腔向血流运输营养物质。这种功能依赖于许多细胞成分的不对称分布，这是一种称为上皮极性的结构组织。上皮细胞的极化结构也塑造器官和动物。我们发现Yrt蛋白是上皮细胞极性的重要调节因子。为了解释这种蛋白质是如何工作的，我们使用果蝇作为模式生物。使用这个易于处理的遗传模型，我们将识别所有与以下功能相关的基因：

Epithelia, composed of epithelial cells, delimit the frontier between the external environment and the inside of complex organisms. Therefore, epithelial cells cover the surface of the body (e.g. skin) and line internal cavities of organs (found in the intestine, lungs, liver, etc). An important function of epithelia is to selectively transport molecules, for instance nutrients from the intestinal lumen toward the bloodstream. This function relies on the asymmetric distribution of many cellular constituents, a structural organization referred to as epithelial polarity. The polarized architecture of epithelial cells also shapes organs and animals. We discovered that the protein Yrt is a crucial regulator of epithelial cell polarity. To decipher how this protein works, we use the fruit fly as model organism. Using this tractable genetic model, we will identify all genes functionally related to