Deciphering the reductive pathways in phagosomes and lysosomes.

吞噬体是吞噬细胞如巨噬细胞和树突状细胞吞噬物质后形成的细胞器。吞噬体内腔是一个动态的、复杂的微环境。在组织重塑、生长和体内平衡过程中，它是微生物杀灭、抗原的精确蛋白水解加工和大分子降解和再循环的场所。尽管吞噬体很重要，但我们对其功能和功能障碍的理解仍存在重大差距。一个特别的空白是氧化还原化学对吞噬体功能的影响。

Phagosomes are organelles that are formed after the engulfment of material by phagocytes such as macrophages and dendritic cells. The lumen of phagosome is a dynamic and complex microenvironment. It is the site of microbial killing, precise proteolytic processing of antigens and the degradation and recycling of macromolecules during tissue remodeling, growth and homeostasis. Despite the importance of the phagosome, there are critical gaps in our understanding of its function and dysfunction. One particular gap is the impact of redox chemistries on phagosomal function.