Contribution of phospholipase A2 enzymes in the homeostasis of the immune system

免疫系统将自我与非自我区分开来，防止外来生物或其他种类的侮辱对身体造成损害。为了保证免疫系统的稳态，多种机制对免疫系统进行了严密的调控。现在人们认识到，一个复杂的微生物生态系统，称为微生物群，与哺乳动物共生并调节免疫反应。在我们的NSERC计划中，我们考虑了水解磷脂的杀菌酶，称为磷脂酶A2 (PLA2)，在免疫系统调节中的作用。

The immune system distinguishes the self from the non-self, preventing foreign organisms or other sort of insults from damaging the body. To ensure of its homeostasis, multiple mechanisms tightly regulate the immune system. It is now appreciated that a complex ecosystem of microorganisms, referred to as the microbiota, lives in symbiosis with mammals and modulates immune responses. In our NSERC program, we consider the role of bactericidal enzymes hydrolyzing phospholipids, called phospholipase A2 (PLA2), in the regulation of the immune system.