Regulation of seamless tube development

在多细胞生物体中，生物管构成许多器官的基本结构。它们的功能是长距离运输气体，液体和细胞，以提供生长和发育所需的基本因素。肾、肺和脉管系统几乎完全由管组成，并且这些管以多细胞（上皮）和单细胞（无缝）单位存在。虽然这些管可以以许多不同的方式发展，但它们都具有共同的特征，即顶端表面衬着管腔。这项研究计划的长期目标是了解利用线虫蛔虫排泄细胞发育生物管的机制

Biological tubes make up fundamental structures of many organs in multicellular organisms. They function to transport gases, fluids and cells over long distances to supply essential factors necessary for growth and development. Kidneys, lungs and vasculature are comprised almost entirely of tubes, and these exist as both multicellular (epithelial) and unicellular (seamless) units. Although these tubes can develop in many different ways they all share the common feature of an apical surface lining the lumen. The long-term goals of this research program are to understand the mechanisms by which biological tubes develop using the excretory cell of the nematode roundworm