Mechanisms of neural specification and patterning during planarian brain regeneration

几十年来，人们对许多模式生物胚胎中的神经发育进行了细致的描述，这些研究表明，神经发育是神经干细胞在空间和时间上的精确协调，以形成具有适当细胞类型比例的功能神经系统。然而，尚不清楚这些发育原则如何适用于成年生物体，因为神经元在损伤后被翻转（稳态）或替换（再生）。在我们的第一个NSERC资助期，我们开始使用淡水涡虫（扁虫）研究成虫神经稳态和再生；

Decades of elegant work have described neural development in the embryos of many model organisms, which has shown that neural development is the precise coordination of neural stem cells in space and time in order to make a functioning nervous system with appropriate cell-type ratios. However, it is not known how these developmental principles apply to adult organisms as neurons are turned over (homeostasis) or are replaced following injury (regeneration). In our first NSERC funding term, we started to investigate adult neural homeostasis and regeneration using the freshwater planarian (flatworm;