Regulation of Mesenchymal Stem Cell Differentiation by Chemerin/CMKLR1

间充质干细胞(MSCs)是一种多能基质细胞，具有向成骨细胞、成骨细胞和储存脂肪的脂肪细胞等多种特化细胞分化的能力。在MSC分化过程中，全球基因表达谱发生变化，与多能性相关的基因被抑制，而特定细胞表型所需的基因被激活。这需要组蛋白乙酰转移酶/脱乙酰基酶(HATS/HDACs)等染色质重塑酶的协同作用。这些蛋白质还通过翻译后修饰影响与特定谱系相关的关键转录因子的功能。我们已经确定了一种分泌蛋白趋化蛋白，它通过激活一种称为趋化素样受体1(CMKLR1)的细胞表面受体对MSC的分化产生强大的影响。我们已经证明了

Mesenchymal stem cells (MSCs) are multipotent stromal cells with the ability to differentiate into several specialized cell types including bone forming osteoblasts and fat storing adipocytes. During MSC differentiation, global gene expression profiles change such that genes associated with multipotency are repressed and those required for the specialized cell phenotype are activated. This requires the coordinated action chromatin remodeling enzymes such as histone acetyltransferases/deacetylases (HATs/HDACs). These proteins also affect the function of key transcription factors associated with specific lineages through post-translational modification. We have identified a secreted protein, chemerin, which exerts a powerful influence on MSC differentiation by activating a cell surface receptor termed chemokine-like receptor 1 (CMKLR1). We have shown that