Cell-matrisome interactions as a key component of the intestinal stem cell niche

肠道内衬单层上皮细胞，确保营养吸收。为了克服肠道环境的累积损伤，这些细胞在我们的一生中迅速补充。位于腺体下部的干细胞群负责不断产生新细胞。与其他器官一样，肠道中的干细胞被限制在微环境受到严格调控的特定区域：生态位。在过去的十年里，我们对肠道干细胞生态位组织的了解在表征调节干细胞性的可溶性效应物方面取得了显着进展。然而，关于肠干细胞生态位组织的几个问题仍然是开放的。例如：干细胞如何保持锚定在腺体的底部？什么是调节龛中不同类型干细胞之间的稳态的机制？

The intestine is lined with a single layer of epithelial cells that ensure nutrient uptake. To overcome cumulative damages from the intestinal environment, these cells are replenished rapidly throughout our lifetime. A stem cell population, located in the lower region of the glands, is responsible for the continual production of new cells. As in other organs, stem cells in the intestine are confined to a specific region where the microenvironment is tightly regulated: the niche. Our knowledge about the organization of the intestinal stem cell niche has significantly progressed over the last decade for the characterization of the soluble effectors that regulate stemness. However, several questions about intestinal stem cell niche organization remain open. For instance: How do stem cells remain anchored at the base of the glands? What are the mechanisms that regulate the homeostasis between the different types of stem cells present in the niche?