Impact of BHV-1 tegument proteins on the innate response to infection and virion morphogenesis.

牛疱疹病毒-1 （BoHV-1）对生长、牛奶生产和国际牲畜贸易产生严重影响，因此对世界范围内的养牛业造成重大经济损失。在北美，BoHV-1是牛呼吸道疾病的一部分，每年使养牛业损失10亿美元。此外，BoHV-1是水牛中出现的一种新病毒。疱疹病毒由四个同心的区室组成：核蛋白核、衣壳、被皮和包膜。被膜蛋白首先与细胞内环境相互作用，并在后期形成新的病毒粒子的被膜。一些疱疹病毒被膜蛋白具有重要的功能，例如调控转录和病毒形态发生。BoHV-1被膜形成的机制、部位及其蛋白组分的功能在很大程度上是未知的。

Bovine herpesvirus-1 (BoHV-1) has a severe impact on growth, milk production, and international livestock trade, thus being responsible for major economic damage to the cattle industry worldwide. In North America BoHV-1 is part of the bovine respiratory disease complex, which costs the cattle industry >1 billion dollars each year. In addition, BoHV-1 is an emerging virus in buffalo. Herpesviruses are composed of four concentric compartments, the nucleoprotein core, capsid, tegument and envelope. Tegument proteins are the first to interact with the intracellular environment and at a later stage associate to create the tegument of new virions. Some herpesvirus tegument proteins have important functions, for instance in regulation of transcription and in virus morphogenesis. The mechanism and site of BoHV-1 tegument formation, and the functions of its protein components are largely unknown.