MET and p66SHC interactomes and functions

消化道肠道上皮的完整性是由其快速更新所确保的。这涉及到各种肠上皮细胞(IEC)时空协调的增殖、迁移、分化和生存。这些细胞过程由IECS和相邻细胞产生的生长因子信号决定。肝细胞生长因子(HGF)是一种通过激活上皮细胞中的受体酪氨酸激酶(RTK)来促进和维持多种器官的组织结构的分子。一些证据表明MET/HGF受体轴在肠上皮细胞的更新中可能起关键作用，但HGF或MET缺陷小鼠的早期胚胎死亡极大地限制了其研究。

The integrity of the intestinal epithelium of the digestive tract is ensured by its rapid renewal. This involves spatiotemporal coordinated proliferation, migration, differentiation and survival of various intestinal epithelial cells (IEC). These cellular processes are dictated by growth factor signals produced by IECs and adjacent cells. Hepatocyte growth factor (HGF) is a molecule promoting and maintaining tissue organization in various organs by activating the receptor tyrosine kinase (RTK) MET in epithelial cells. Several lines of evidence suggest that the MET/HGF receptor axis may play a key role in the renewal of the intestinal epithelium, but the early embryonic death of HGF- or MET-deficient mice have greatly limited its study.