Role of Misshappen (NIK/Msn) kinases and Extended-Synaptotagmins (E-Syts) in Wnt and FGF intracellular signaling pathways.

细胞间的信号传递是决定后生动物体型和控制生长和分化的基础。因此，大量的信号分子家族及其同源受体已经进化，使早期发育、器官发生和动态平衡的复杂性成为可能。其中几个家族在早期发育过程中起重要作用，特别是无翼(WNT)和成纤维细胞生长因子(FGFs)家族。它们在发育过程中扮演着不同但又相互关联的角色，并通过不同的和共享的转导途径发挥作用。我们已经确定了成纤维细胞生长因子和Wnt信号通路的新元件，它们为了解信号和通路间串扰的重要方面提供了潜在的窗口。我们提出的机制研究将为细胞内信号传递的复杂网络提供新的见解。

Signalling between cells is fundamental to determining the metazoan body plan and in controlling growth and differentiation. Hence, a large number of families of signalling molecules and their cognate receptors have evolved to enable the complexities of early development, organogensis and homeostasis. Several of these families are of importance during early development, in particular the Wingless (Wnt) and Fibroblast Growth Factors (FGFs) families. These play separate, but interrelated, roles during development and act through distinct as well as shared transduction pathways. We have identified novel elements of the FGF and Wnt signalling pathways that provide potential windows into important aspects of signalling and inter-pathway crosstalk. We propose mechanistic studies that will provide new insight into the complex network of intracellular signalling.