Binding of Endophilin Endocytic Proteins to AMPA Receptors and Neuronal Voltage-gated Potassium (Kv) Channels: Regulation of Synaptic Plasticity

这项发现资助主要集中在离子通道的细胞生物学和神经组织兴奋性的调节以及学习和记忆。电压门控钾（Kv）通道和称为AMPAR的配体门控谷氨酸受体在人脑中执行许多功能，分别包括维持静息膜电位和调节记忆形成突触可塑性。钾通道Kv家族的几个成员，即Kv1.5，Kv4.2和HERG通道，以及AMPAR在大脑的一个区域中表达，称为海马体，负责编码和储存记忆。

This Discovery Grant is focused on the cellular biology of ion channels and regulation of nervous tissue excitability and learning and memory. The voltage-gated potassium (Kv) channels and ligand-gated glutamate receptors called AMPARs perform many functions in the human brain, including maintenance of resting membrane potential and regulation of memory-forming synaptic plasticity, respectively. Several members of the Kv-family of potassium channels, namely the Kv1.5, Kv4.2 and HERG channels, and AMPARs are expressed in an area of the brain, called the hippocampus, which is responsible for encoding and storing memory.