The regulation of the intestinal epithelium and host-pathogen interactions by the constitutive androstane receptor

约翰氏病是反刍动物的一种消瘦状态，由感染禽类副结核分枝杆菌(MAP)引起，该疾病通过受污染的牛奶和粪便-口腔途径传播。由于约翰氏病的体征和症状通常需要数年时间才能形成(在此期间，MAP可能会从粪便中脱落)，因此很难实施传统的监测方法来减少其传播。为了限制家畜和天然反刍动物感染疾病的负担，我们必须了解导致病原体传播、入侵和宿主炎症反应的步骤。

Johne’s disease, a wasting condition in ruminants, is caused by infection with Mycobacterium avium subspecies paratuberculosis (MAP), which is transmitted via contaminated milk and through the fecal-oral route. Since signs and symptoms of Johne’s disease often take years to develop (during which MAP can be shed in the feces), it is difficult to implement traditional surveillance methods to reduce its spread. To limit the burden of infectious disease in livestock and natural ruminants we must understand the steps that lead to pathogen transmission, invasion and the host inflammatory response.