New approaches to carbon-11 labeled carbonyl and thiocarbonyl groups for positron emission tomography radiotracer synthesis and development

碳-11是一种半衰期为20.3分钟的短寿命放射性同位素，在生物化学研究、药物开发和诊断医学成像方面具有重要应用。由于碳原子形成所有有机化合物和几乎所有生物分子、药物和成像剂的骨架，碳-11是制备这些标记类似物用于成像而不改变其在生命系统中的行为的最通用的同位素。为了合成具有碳-11的成像剂，需要在严格控制的条件下以高效率快速连续地进行化学转化，以确保可重复的结果以及产品的安全性和实用性。我们的研究项目开发了碳-11的改进化学方法和使用这种同位素的新成像剂。具体地说，我们认为，将高氧化态碳-11标记物从其生产形式（如二氧化碳和类似衍生物，如一氧化碳和氰化物）掺入分子中的方法将大大扩展这种同位素的合成武器，并直接导致可用于分子成像的新型和改进的放射性药物。

Carbon-11 is a short-lived radioactive isotope with a half-life of 20.3 minutes, and which has important applications for biochemistry research, drug development, and diagnostic medical imaging. Since carbon atoms form the backbone of all organic compounds and nearly all biomolecules, drugs, and imaging agents, carbon-11 is the most versatile isotope for preparing labeled analogues of these for imaging without changing their behaviour in living systems. To synthesize imaging agents with carbon-11, chemical transformations need to be performed in rapid succession with high efficiency under strictly controlled conditions to ensure reproducible results and the safety and utility of products. Our research program develops improved chemical methods with carbon-11 and new imaging agents using this isotope. Specifically, we believe that methods for incorporating high oxidation state carbon-11 labels into molecules from its production form as carbon dioxide and similar derivatives such as carbon monoxide and cyanide will greatly expand the synthetic armament for this isotope and directly lead to novel and improved radiopharmaceuticals available to power molecular imaging.