Discovery of new catalytic reactions through mechanistically guided screening

纽曼集团的研究重点是现代技术在基础和应用化学领域的应用。特别是，我们正在探索使用高通量实验(HTE)和流动化学平台来合成有价值的分子。这项建议的重点是应用热膨胀技术来发现容易获得的构件的均相催化反应。作为一个年轻的研究团队，我们的目标是承担具有高影响力的项目，目的是建立一个独特的、世界级的研究计划。这将通过三个阶段进行：1)反应发现、优化和机理阐明；2)应用于药物和生物质衍生的大宗化学品的合成；3)利用我们对催化的日益增长的理解来进一步反应发展。这项研究计划描述了第一阶段的5年计划，发现新的化学反应，包括新的C-C交叉偶联反应，原子经济的烯醛偶联反应和N

Research in the Newman group focuses on the application of modern technologies to the advancement of fundamental and applied chemistry. In particular, we are exploring the use of high throughput experimentation (HTE) and flow chemistry platforms for the synthesis of valuable molecules. This proposal focuses on the application of HTE to the discovery of homogeneously catalyzed reactions of readily available building blocks. Being a young research group, our goal is to take on high impact projects with the intention of establishing a unique, world-class research program. This will occur through three phases: 1) Reaction discovery, optimization, and mechanism elucidation; 2) Application to the synthesis of pharmaceuticals and biomass-derived bulk chemicals; and 3) Use of our increased understanding of catalysis for further reaction development. This research proposal describes a 5 year plan for phase 1, discovery of new chemical reactions, including a new C–C cross-coupling reaction, an atom economical olefin-aldehyde coupling, and an N