Transport modeling for multi-modality contrast-enhanced imaging

动态对比增强（DCE）成像的使用正在迅速成为了解各种疾病和干预措施的重要工具。这在其他领域也很关键，从工程和化学到结构和细胞生物学。目前，DCE成像能够通过血流和灌注评估组织功能。我们最近的工作表明，目前的动力学模型的可靠性大大降低，在组织缺氧和高压。获得更多关于组织微环境条件的信息将有助于阐明更多的疾病过程，并增加DCE成像用于诊断目的的价值，以及评估药物递送机制的功效和对靶向干预的反应。间质流体压力（IFP）是一个对非侵入性获取有价值的特征-目前IFP的测量需要针头-这种方法只能用于可触及的组织位置，并且难以重复。我们实验室的初步工作表明，这些类型的参数可以从非侵入性DCE成像中获得。

The use of dynamic contrast-enhanced (DCE) imaging is rapidly becoming an important tool to understand a variety of diseases and interventions. This is critical in other fields as well ranging from engineering and chemistry to structural and cell biology. At present DCE imaging is able to assess tissue functionality through blood flow and perfusion. Our most recent work has shown that the reliability of current kinetic models is much reduced in tissues with poor oxygenation and high pressure. Incorporating more information on the micro-environmental conditions of tissue would help illuminate more disease processes and increase the value of DCE imaging for diagnostic purposes and to assess the efficacy of drug delivery mechanisms and the response to targeted interventions.Interstitial fluid pressure (IFP) is one feature that would be valuable to acquire non-invasively—current measurements of IFP require a needle-based approach that can only be used on accessible tissue locations and is difficult to repeat. Preliminary work from our lab indicates that these types of parameters can be derived from non-invasive DCE imaging.