Differences in Nef-mediated SERINC3/5 antagonism across viral subtypes modulates HIV-1 infectivity and pathogenesis

全球约有3700万人感染艾滋病毒-1，这仍然是一个优先关注的公共卫生问题。撒哈拉以南非洲约有2660万病例，是世界上受影响最严重的地区。然而，在撒哈拉以南非洲地区流行的HIV-1亚型中

With ~37 million people infected globally, HIV-1 remains a priority public health concern. With approximately 26.6 million cases, sub-Saharan Africa is the most affected region of the world. However, among the circulating HIV-1 subtypes in sub-Saharan Afr