Investigating neural plasticity induced by EEG Brain-machine interface

无创脑机接口（BMI）作为一种先进的神经可塑性诱导方法正在兴起。共同申请人江博士最近开发了一种非侵入性BMI，利用头皮脑电图（EEG）记录的运动相关皮层电位来触发非侵入性外周神经刺激。EEG - BMI的重复配对导致目标肌肉的神经输出的短期变化。基础研究将探讨脑电- BMI诱发运动皮层、皮质-脊髓通路和运动单位招募变化的神经机制。该研究还将致力于改进EEG - BMI的传递，以最大限度地适应较短持续时间的EEG BMI。麦克马斯特大学的神经生理学家Nelson博士研究感觉运动皮层的神经可塑性，滑铁卢大学的系统工程师Jian博士开创了先进的EEG - BMI方法。所要求的基础设施，EEG - BMI系统将通过带来目前无法获得的尖端技术来增强麦克马斯特的研究能力。这一进展将在理解脑电- BMI诱发的神经可塑性的基础过程方面取得重大进展。该基础设施将在今后五年内充分利用，为大约25名研究生受训人员提供培训，并促进具有互补专门知识的邻近大学之间的合作。

Non-invasive brain machine interfaces (BMI) are emerging as an advanced method to induce neural plasticity in humans. Co-Applicant Dr. Jiang has recently developed a non-invasive BMI that utilizes the movement related cortical potential recorded using scalp electroencephalography (EEG) to trigger the noninvasive delivery of peripheral nerve stimulation. Repeat pairing of the EEG - BMI leads to short-term changes in neural output to the targeted muscle. The proposed foundational research will examine the neural mechanisms by which the EEG - BMI induces changes within the motor cortex, corticospinal pathway and motor unit recruitment. The research will also aim to refine the delivery of the EEG - BMI to maximize the adaptations with shorter duration EEG BMI. The proposed research involves collaboration between neurophysiologist Dr. Nelson at McMaster University who studies neural plasticity in sensorimotor cortex and systems engineer Dr. Jian at the University of Waterloo who has pioneered the advanced EEG - BMI approach. The requested infrastructure, the EEG - BMI system will enhance the research capability at McMaster by bringing a cutting-edge technique that is currently unavailable. This advancement will lead to major strides in understanding the foundational processes that underpin neural plasticity induced by EEG - BMI. The infrastructure will be used at full capacity in providing training to approximately 25 graduate trainees over the next five years and foster collaboration between neighboring universities with complementary expertise.