Development of treatments for canine parvovirus

在传染病中，犬细小病毒是犬发病和死亡的主要原因之一。感染会导致发烧、呕吐、脱水和腹泻。未经治疗，大多数狗将死于感染。目前的治疗依赖于高成本的支持性治疗，如输血，IV喂养和兽医医院的24小时护理。犬细小病毒感染对狗主人来说是非常昂贵的，其中包括三分之一的加拿大家庭。NovoBind畜牧治疗公司提出开发新的基于抗体的策略，可以提供给狗主人以预防犬细小病毒感染，或者可以提供给兽医作为治疗剂给受感染的狗。目前，NovoBind正在生产新型犬细小病毒特异性 ** 抗体（NBXs）。该提案依赖于Nelly Panté博士 ** 及其实验室在细小病毒生物学和细胞生物学领域的专业知识。本文描述的工作将提供 ** 概念验证，证明NovoBind的策略可以阻断犬细小病毒的感染性，并将使NovoBind ** 最终选择针对犬细小病毒的最佳抗体。针对犬细小病毒的预防和治疗产品的开发将使所有狗主人受益，因为它们将为处理犬细小病毒提供更快和更经济的选择。NovoBind在提供 ** 这一产品方面所产生的收入也将对加拿大的经济产生推动作用，因为当狗主人必须放弃工作来照顾他们的狗时，生产力损失的恢复也将如此。

Amongst infectious diseases, canine parvovirus is one of the leading causes of morbidity and mortality in dogs.**Infection results in fever, vomiting, dehydration, and diarrhea. Untreated, most dogs will die from the infection.**Current therapies rely on high-cost supportive therapies, such as blood transfusions, IV feeding, and 24-hour**care at veterinary hospitals. Canine parvovirus infections are very costly to dog owners, which includes a third**of Canadian households. NovoBind Livestock Therapeutics Inc. proposes to develop novel antibody-based**strategies that could be provided to dog owners to prevent canine parvovirus infections or be available to**veterinarians as a therapeutic to be administered to infected dogs. Currently, novel canine parvovirus-specific**antibodies (NBXs) are being generated by NovoBind. This proposal relies on the expertise of Dr. Nelly Panté**and her laboratory in the fields of parvovirus biology and cell biology. The work described here will provide**proof-of-concept that NovoBind's strategy can block canine parvovirus infectivity and will enable NovoBind's**eventual selection of the best antibodies against canine parvovirus. The development of prophylactic and**therapeutic products targeting canine parvovirus would benefit all dog owners as they will provide faster and**more economical options for dealing with canine parvovirus. The revenue generated by NovoBind in delivering**this product would also be an economic boost to Canada as would the recovery of lost productivity that occurs**when dog owners must forgo work to care for their dogs.