Optimization of chemiluminescent sensing microstructures

安吉尔生物科学公司是一家总部位于安大略省多伦多的国际公司，专注于通过各种传感平台分发液体活检**技术。在他们的传感产品中，有一项独特的专利技术**，研究人员可以在一个被称为**Ziplex系统的紧凑桌面工作站上识别样本中的标记。这项技术使用了一系列能够结合目标分子的微观通道，当**样品流经它们时。化学发光(鲁米诺)然后释放光线，使用相机观察到的光**可以快速而清晰地向研究人员表明积极的结果。该系统允许Angel提供一个传感**工作站，通过简单的流体处理比竞争对手的技术更快地提供结果。然而，通过优化微孔的几何形状，可以显著改进该系统中使用的微孔硅敏元件。增加传感元件的光输出将导致较低的检测极限，从而使设备具有**显著的优势。**约翰·西佩教授是光学和光-物质相互作用方面的专家，在开发**简单模型以指导复杂问题的解决方面拥有丰富的经验。该项目的目标将是研究Ziplex系统几何结构变化的影响**，以优化系统设计并增强输出信号。**这将通过利用分析模型来探索潜在的解决方案，然后利用更稳健的**模拟来完成优化。

Angle Biosciences is an international company based in Toronto, Ontario that focuses on distributing liquid biopsy**technology through a variety of sensing platforms. Among their sensing products is a unique, patented technology**that allows researchers to identify markers in their samples in a compact, tabletop workstation known as the**Ziplex system. The technology uses an array of microscopic channels capable of binding target molecules as a**sample flows through them. Chemiluminescence (luminol) then releases light which is observed using a camera to**quickly and clearly indicate the positive result to the researcher. This system allows Angle to offer a sensing**workstation that delivers results faster than competitive technology with simple fluid handling. However, the**micropore silicon sensing element used in this system could be significantly improved through optimization of the**pore geometry. Increasing the light output of the sensing elements would result in a lower detection limit giving a**significant advantage to the device.**Professor John Sipe is an expert in optics and light-matter interactions with a wealth of experience in developing**simple models to guide the solution of complicated problems. The goal of this project will be to study the effects**of varying the geometry of the Ziplex system to optimize the system design and strengthen the output signal.**This will be accomplished by utilizing an analytic model to explore potential solutions before more robust**simulations are utilized to complete the optimization.