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Investigation of Mechanisms Leading to Synthetic Lethality of BRCA-associated Cancers

Investigation of Mechanisms Leading to Synthetic Lethality of BRCA-associated Cancers
BRCA 相关癌症综合致死机制的研究
批准号:
407643
负责人:
Hakem Razqallah
金额:
$4.37万
依托单位国家:
加拿大
项目类别:
Operating Grants
财政年份:
2019
资助国家:
加拿大
项目状态:
已结题
起止时间:
2019-02-01 至 2021-02-01
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中文摘要
翻译
肿瘤抑制基因BRCA1和BRCA2的遗传缺陷显著增加了患乳腺癌和卵巢癌的风险。由于这些缺陷而产生的肿瘤往往具有侵袭性。目前,BRCA1或BRC的健康女性携带者
英文摘要
Inheriting defects in the tumor suppressor genes BRCA1 and BRCA2 significantly increases risk of developing breast and ovarian cancers. Tumors that arise as a result of these defects tend to be aggressive. Currently, healthy women carriers of BRCA1 or BRC
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会议论文
Targeting transcription-replication conflicts as vulnerabilities in BRCA1 mutant and homologous recombination-deficient breast and ovarian cancers
  • 批准号:
    469737
  • 项目类别:
    Operating Grants
  • 资助金额:
    $69.66万
  • 财政年份:
    2022
  • 负责人:
    Hakem Razqallah
  • 依托单位:
Novel contrasting functions of RNF168 and RNF169 in breast cancer and therapeutic implications.
Investigation of the crosstalk of DNA Double strand break signaling/repair with Notch and Wnt signaling pathways; and determination of their roles in cancer development and therapies.
  • 批准号:
    313498
  • 项目类别:
    Operating Grants
  • 资助金额:
    $136.86万
  • 财政年份:
    2014
  • 负责人:
    Hakem Razqallah
  • 依托单位:
Examination of the effect of posttranslational modifications of 53BP1 in development and diseases
  • 批准号:
    226562
  • 项目类别:
    Operating Grants
  • 资助金额:
    $33.69万
  • 财政年份:
    2011
  • 负责人:
    Hakem Razqallah
  • 依托单位:
海外基金