Back to the future: fast and accurate identification of shared genomic segments for disease gene mapping using population-based linkage analysis to take advantage of founder effects

对许多疾病的遗传学研究主要集中在有多个受影响个体的家庭。现在这些家庭中的大多数已经确定了他们的疾病的遗传原因，仍然有许多患者没有已知的受影响的亲属

Genetic studies of many diseases have focused on families with multiple affected individuals. Now that most of these families have a genetic cause identified for their disease, there still remain many people with disease who have no known affected relativ