Synergising nanoemulsion and lipid biomimetic design for advanced delivery

该项目旨在确定脂质修饰探针或药物(脂质仿生学)的脂质制剂的关键设计特征，这些探针或药物共同促进整合到脂质吸收途径中，并以排出小肠的淋巴系统为目标。这具有巨大的潜力，因为肠道淋巴系统是关键的免疫组织，是对自身抗原和来自食物和微生物组的抗原进行免疫反应的场所。该项目将提供淋巴靶向所需特征的设计路线图，特别是将确定与脂质生物仿生协同工作的新型脂质纳米乳剂，以增强淋巴成像和递送应用。

This project aims to identify the critical design characteristics of lipid formulations of lipid-modified probes or drugs (lipid biomimetics) that together promote integration into lipid absorption pathways and target the lymphatic system that drains the small intestine. This has significant potential since the intestinal lymphatic system is a key immune tissue, the site of immune response to autoantigens and antigens derived from food and the microbiome. The project will deliver a design roadmap of the required characteristics for lymphatic targeting, and in particular, will identify novel lipid nanoemulsions that work synergistically with lipid biomimetics to enhance lymphatic imaging and delivery applications.