Functional Derivatives of Maleic Acid copolymers and Native Nanodisc Technology (FUNDEMANNT) [Phase 1]

Tec Edmonton于2019年10月23日提交了一份美国临时专利申请，介绍了Overduin博士的发明，涉及一系列用于增溶、纯化、操纵和可视化疏水材料(如脂类或膜蛋白)的马来酸共聚物的功能化衍生物、在所述共聚物和疏水材料之间形成的水溶性纳米盘、所述络合物的制备方法以及所述络合物的应用，尤其是在分析、筛选或诊断方面的应用。美国的临时专利申请将在2020年10月23日之前转化为正式的PCT申请，届时将纳入有关使用这种共聚物和方法与额外的细胞、组织和膜蛋白质形成纳米盘以及伴随的生物物理和生化特性的新数据。随后的国家阶段截止日期将继续进行，以维持美国、加拿大和欧洲的专利保护，以便进行未来的研究并保持行业兴趣。根据过去的支出，我们估计我们在上述司法管辖区的总申请成本将为10,000美元，我们要求由I2I资金偿还一半。在授予过程中，我们将继续与潜在的被许可方接触，以确保互惠互利，并将努力实现我们的目标，即获得许可协议和合同服务。

TEC Edmonton filed a US provisional patent application on October 23, 2019 that describes Dr. Overduin's invention relating to a series of functionalized derivatives of maleic acid copolymers which are used for solubilization, purification, manipulation and visualization of hydrophobic materials such as lipids or membrane proteins, the water-soluble nanodiscs formed between said copolymers and hydrophobic materials,methods for preparing said complexes, and the applications of said complexes, particularly to analytical, screening or diagnostic purposes. The US provisional patent application will be converted to a formal PCT application by October 23, 2020, at which point new data will be incorporated regarding the use of this copolymers and methods with additional cells, tissues, and membrane proteins to form nanodiscs as well as accompanying biophysical and biochemical characterization. The subsequent national phase deadline will be pursued in order to maintain patent protection in the US, Canada, and Europe to allow for future research and to retain industry interest. Based on past expenditures, we estimate that our total filing costs in the aforementioned jurisdictions will be $10,000, for which we are asking half to be reimbursed by I2I funding. Over the course of this grant, we will continue to engage with potential licensees to ensure mutual ongoing benefit, and will work towards our goal of securing license agreements and contract services.