Development of Targeted Therapies for the Treatment of Mixed Lineage Leukemia
Development of Targeted Therapies for the Treatment of Mixed Lineage Leukemia
批准号:
467032
负责人:
Hendrickson-Rebizant Thordur D
金额:
$1.27万
依托单位:
依托单位国家:
加拿大
项目类别:
Studentship Programs
财政年份:
2021
资助国家:
加拿大
项目状态:
已结题
起止时间:
2021-12-01 至 2022-12-01
中文摘要
端粒沉默破坏因子1样(DOT1L)是一种组蛋白甲基转移酶,一种将氢原子添加到组蛋白H3上的氨基酸赖氨酸79上的蛋白质。在正常生理条件下,DOT1L甲基化导致基因表达增加,
英文摘要
Disruptor of telomeric silencing 1-like (DOT1L) is a histone methyltransferase, a protein that adds hydrogen atoms onto the amino acid lysine 79 on histone H3. In normal physiological conditions, methylation by DOT1L leads to increased gene expression, th
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