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Novel CTRP8-DLK1 interaction alters NOTCH1 signaling to support tumor stem cells

Novel CTRP8-DLK1 interaction alters NOTCH1 signaling to support tumor stem cells
新型 CTRP8-DLK1 相互作用改变 NOTCH1 信号传导以支持肿瘤干细胞
批准号：
466631
负责人：
Arreza Leanne
金额：
$1.27万
依托单位：
University of Manitoba
依托单位国家：
加拿大
项目类别：
Studentship Programs
财政年份：
2021
资助国家：
加拿大
项目状态：
已结题
起止时间：
2021-12-01 至 2022-12-01
来源：
https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=466631&lang=en
关键词：
Brain Tumors C1q-Tumor Necrosis Factor-Related Protein 8 Cancer Biology Cancer Stem Cells Delta-Like Homolog Protein 1 Glioblastoma Innate Immune Cells Innate Immune System Protein Interactions Tumor Microenvironment

项目摘要

项目成果

相关文献

中文摘要
翻译
肿瘤内不同细胞类型的网络，如癌症干细胞和免疫细胞，调节肿瘤的生长和存活。目前的药物在靶向破坏癌症干细胞方面是无效的，这使得这些细胞能够保持它们的状态
英文摘要
A network of different cell types within a tumor, such as cancer stem cells and immune cells, regulates tumor growth and survival. Current drugs are ineffective in the targeted disruption of cancer stem cells, which enables these cells to retain their pot
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