Barriers to the transmission of multidrug-resistance conjugative plasmids of the IncC group: surface exclusion, entry exclusion and anti-restriction

随着20世纪30年代第一批抗生素的发现和使用，与传染病有关的死亡率和发病率大大降低。然而，多年来，抗生素的使用、滥用和误用选择了“超级细菌”

With the discovery and use of the first antibiotics during the 1930s, the mortality and morbidity associated with infectious diseases have considerably decreased. However, over the years, the usage, abuse and misuse of antibiotics have selected "superbugs