Population genomics of evolutionary conflicts

尽管在同一个基因组中发现，不同基因的进化利益，甚至单个基因内的突变可能相互冲突。例如，在植物中，赋予花粉繁殖成功竞争优势的突变可能对植物生命周期的其他阶段产生有害的副作用。同样，自私的遗传因素，增强了自身的传播能力，可以在种群中传播，尽管对生物体有潜在的有害健康影响。虽然这些情况在理论上已经得到了很好的描述，并且全基因组序列的日益可用性揭示了自私的遗传因素在基因组中的主导地位，但这些冲突对维持遗传多样性和推动基因组进化的进化重要性仍然知之甚少，这是该补助金的重点。该建议旨在解决几个主要的开放性问题，包括：1）花粉竞争有多少遗传变异，以及自然选择如何作用于这种变异？2)自私遗传因子在植物种群Y染色体退化中起重要作用吗？3)交配系统和倍性（个体拥有的基因组拷贝数）的进化转变会影响自私遗传因子的进化命运吗？4）增加基因表达的突变是否通过掩盖有害突变而在人群中传播？ 通过研究基因组和基因表达变异的模式，我们希望获得重要的新的见解进化冲突的重要性，在维持遗传多样性和构建基因组的进化。

Despite being found within the same genome, the evolutionary interests of different genes, and even  mutations within single genes can conflict with each other. In plants for example, mutations that confer a competitive advantage to pollen for reproductive success may have harmful side-effects on other phases of the plant's life-cycle. Similarly, selfish genetic elements, which enhance their own ability to transmit themselves, can spread through populations, despite the potential for harmful fitness effects on the organism. While these cases have been well characterized theoretically, and the growing availability of whole genome sequences has revealed the predominance of selfish genetic elements across genomes, the evolutionary importance of these conflicts for maintaining genetic diversity and driving genome evolution remains poorly understood, and is a focus of this grant. This proposal aims to address several major open questions including: 1) How much genetic variation is there for pollen competition, and how does natural selection act on this variation? 2) Do selfish genetic elements play an important role in the degeneration of Y chromosomes in plant populations?, 3) Do evolutionary transitions in mating system and ploidy (the number of genome copies an individual has) influence the evolutionary fate of selfish genetic elements?, and 4) Do mutations that increase the expression of genes spread through populations by masking harmful mutations? By studying patterns of genome and gene expression variation, we hope to gain important new insights into the importance of evolutionary conflicts in maintaining genetic diversity and structuring the evolution of genomes.