High resolution magic angle spinning NMR probe for biological tissue samples

申请资金用于高分辨率魔角旋转（HR-MAS）核磁共振（NMR）探针。与传统的核磁共振探针相比，HR-MAS探针提供了无与伦比的信号灵敏度和光谱分辨率。HR-MAS探针与纽芬兰纪念大学的高场固态核磁共振光谱仪相结合，将成为核磁共振设施的强大工具，并将使许多学术单位的科学家的研究受益。固体组织样品的HR-MAS探针的独特技术设计导致显着狭窄的线形状（类似于溶液核磁共振实验！），同时保持生物组织样品的完整性。该探测器将使林赛·s·卡希尔博士（早期化学研究人员）领导的资助研究能够研究大脑和胎盘中的化学物质在整个妊娠期间是如何变化的。这些信息对提高我们对大脑和胎盘功能的理解至关重要，并允许识别对妊娠期间常规诊断测试发展至关重要的分子。卡希尔博士将通过研究实验小鼠的大脑和胎盘组织样本以及人类怀孕的胎盘组织样本来实现这些目标。这项工作有可能通过更好地了解新陈代谢，显著提高妇女和胎儿的健康。

Funding is requested for a high resolution magic angle spinning (HR-MAS) nuclear magnetic resonance (NMR) probe. Compared to traditional NMR probes, the HR-MAS probe provides unparalleled signal sensitivity and spectral resolution. The HR-MAS probe, combined with the high field solid-state NMR spectrometer at Memorial University of Newfoundland, will become a powerful tool in the NMR facility and will benefit the research of many scientists across academic units. The unique technical design of the HR-MAS probe for solid tissue samples results in significantly narrow line shapes (similar to solution NMR experiments!) while maintaining the integrity of the biological tissue sample. The probe will enable funded research led by Dr. Lindsay S. Cahill (early career researcher in Chemistry) to study how chemicals in the brain and placenta change throughout gestation. This information is critical to improve our understanding of brain and placental function and allows identification of molecules that are essential for development of routine diagnostic tests during pregnancy. Dr. Cahill will accomplish these goals by studying brain and placental tissue samples from experimental mice and placental tissue samples from human pregnancies. This work has the potential to significantly enhance women's and fetal health through a better understanding of metabolism.