Multichannel arbitrary waveform generator for sub-nm resolution nuclear magnetic resonance diffraction imaging measurements of protein nanocrystals and quantum transport studies

量子技术的快速发展将从根本上改变我们在原子尺度上处理信息、通信和图像材料的方式。在过去的十年中，Budakian开发了一种新的高分辨率纳米级磁共振成像(MRI)平台，将超灵敏自旋检测与高保真自旋控制相结合。实现原子分辨率是核磁共振的终极极限，而实现这一能力提供了巨大的技术和科学机会，从药物开发到了解相互作用的量子系统的复杂动力学。2020年，Budakian获得了专利核磁共振(核磁共振)衍射(NMRd)-一种新的技术，用于成像具有亚纳米分辨率和元素选择性的晶体材料的三维结构。布达克小组的长期目标是应用NMRd来阐明蛋白质分子结构，并作为一种工具在原子尺度上研究相互作用的量子系统的动力学。Budakian请求为购买低噪声6通道任意波形发生器提供资金，该发生器将用于产生实施NMRd所需的复杂电压波形。该仪器将提供重要的能力，推动布达金团队在两个重要领域的研究。以原子分辨率和化学选择性成像蛋白质的能力为理解蛋白质相互作用提供了一种强大的新方法，并可能导致变革性的新药物疗法。虽然这种能力超出了现有成像技术的能力范围，但尖端技术，如NMRd，可以为蛋白质结构提供新的见解。通过购买所需的仪器，Budakian将建立一个研究计划，开发NMRd，以亚纳米分辨率和元素对比度对结构蛋白质纳米晶体进行成像。在量子通信和计算领域，人们对了解量子信息在量子网络中的传播速度非常感兴趣。为了解决这个问题，NMRd将被用于研究中的相互作用，这些相互作用控制着量子信息在大范围长度尺度上的传播，一直延伸到原子尺度。该仪器将使该团队能够为设计用于量子通信和计算的高效量子网络贡献新的专业知识。对于布达金的团队来说，要想在药物输送和量子信息研究方面保持竞争力，NMRD是必不可少的。这是从量子控制序列的理论设计到其在物理系统上的实现之间获得反馈的唯一手段。HQP使用该仪器的经验及其在量子力学、凝聚态物理和核磁共振光谱学方面的尖端研究将使他们在未来的学术界和量子行业的职业生涯中具有竞争力。

The rapid growth of quantum technologies is poised to fundamentally alter the way we process information, communicate, and image materials at the atomic scale. During the past decade, Budakian has developed a new platform for high-resolution nanoscale magnetic resonance imaging (MRI) that incorporates ultra-sensitive spin detection with high-fidelity spin control. Achieving atomic resolution is the ultimate limit of MRI, and attaining this capability offers huge technological and scientific opportunities, from drug development to understanding the complex dynamics in interacting quantum systems. In 2020, Budakian received a patent nuclear magnetic resonance (NMR) diffraction (NMRd)-a new technique for imaging the three-dimensional structure of crystalline materials with sub-nm resolution and elemental selectivity. The long-term goal of the Budakian group is to apply NMRd to elucidate the structure of protein molecules, and as a tool to study the dynamics of interacting quantum systems on the atomic scale. Budakian requests funding for the purchase of a low noise 6-channel arbitrary waveform generator, which will be used to generate the complex voltage waveforms needed to implement NMRd. This instrument will provide important capabilities to advance the research of Budakian's team in two important areas. The ability to image proteins with atomic resolution and chemical selectivity provides a powerful new approach to understanding protein interactions, and could potentially lead to transformative new drug therapies. While this capability lies beyond the reach of existing imaging techniques, cutting-edge techniques, such as NMRd, could provide new insight into protein structure. With the purchase of the requested instrument, Budakian will establish a research program to develop NMRd to image the structure protein nanocrystals with sub-nm resolution and elemental contrast. In the areas of quantum communication and computing, there is great interest to understand the speed with which quantum information propagates in quantum networks. To address this problem, NMRd will be applied to study the interactions in that govern the propagation of quantum information over a wide range lengthscales, extending down to the atomic scale. The instrument will enable to the team to contribute new expertise to designing efficient quantum networks that are used in quantum communication and computing. For Budakian's team to remain competitive in research into drug delivery and quantum information the NMRd is a must have. It is the only means to gain feedback between the theoretical design of quantum control sequences and their implementation on physical systems. HQP's experience with the instrument and the cutting-edge research it will enable in quantum mechanics, condensed matter physics and NMR spectroscopy will position them competitively in future careers in academia and quantum industries.