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Application of physiologically-based pharmacokinetic (PBPK) models to assess food effects on oral absorption and evaluate metabolic consequences of cytochrome P450 induction

Application of physiologically-based pharmacokinetic (PBPK) models to assess food effects on oral absorption and evaluate metabolic consequences of cytochrome P450 induction
应用基于生理的药代动力学 (PBPK) 模型评估食物对口服吸收的影响并评估细胞色素 P450 诱导的代谢后果
批准号:
570107-2022
负责人:
Cheng, LisaLKY
金额:
$1.53万
依托单位国家:
加拿大
项目类别:
Postgraduate Scholarships - Doctoral
财政年份:
2022
资助国家:
加拿大
项目状态:
已结题
起止时间:
2022-01-01 至 2023-12-31

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中文摘要
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英文摘要
physiologically-based models, pharmacokinetics, modeling and simulation, food effects, oral absorption, gastrointestinal pH, enzyme induction, cytochrome P450s, pregnane X receptor, xenobiotic interactions
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