Understanding mechanistic and systemic regulation of protein prenyltransferases

这项研究将扩大我们对脂质结合酶的理解，这些酶对许多正常细胞功能至关重要。我们试图揭示细胞的基本运作，并帮助解释真核生物进化中信号网络的发展和复杂性。这些发现将使我们能够探索和利用这些脂质相关酶的催化特性，用于生物技术。最终目标是创造新的蛋白质生产、修饰和分析技术，加快蛋白质研究、基础细胞和生物体生物学、诊断学、生物技术和药物发现的步伐。

The proposed research will expand our understanding of lipid-conjugating enzymes that are critical for a multitude of normal cellular functions. We seek to reveal the basic workings of cells and help to explain the development and complexity of signalling networks in eukaryotic evolution. The findings will enable us to explore and exploit the catalytic properties of these lipid-related enzymes for applications in biotechnology. The ultimate aim is to create novel technologies for protein production, modification and analysis that will accelerate the pace of discovery in protein research, basic cell and organism biology, diagnostics, biotechnology and drug discovery.