Characteristic cytosolic DNA patterns produced by genomic instability induce anti-tumour immunity via cGAS/STING in colorectal cancer
Characteristic cytosolic DNA patterns produced by genomic instability induce anti-tumour immunity via cGAS/STING in colorectal cancer
批准号:
495184
负责人:
Mosley Shayla
金额:
$0.11万
依托单位:
依托单位国家:
加拿大
项目类别:
财政年份:
2023
资助国家:
加拿大
项目状态:
已结题
起止时间:
2023-10-01 至 2024-10-01
关键词:
中文摘要
当微生物进入人体时,外来DNA被携带到细胞内,并激活被称为模式识别受体(PRR)的传感器。这会激活免疫系统,消除感染。在肿瘤细胞中,不稳定的肿瘤DNA和HIG
英文摘要
When microbes enter the body, foreign DNA is carried into cells and activates sensors termed pattern recognition receptors, or PRRs. This leads to activation of the immune system and elimination of the infection. In tumor cells, unstable tumor DNA and hig
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