基于天人相应理论的过敏性鼻炎的研究- - -季节气候变化对过敏性鼻炎免疫应答的影响

过敏性鼻炎是临床常见的变态反应性疾患，该病发生与地区、季节和环境气候变化紧密相关，之所以出现这一特点主要与机体自身免疫功能失调关系紧密。为探讨过敏性鼻炎的免疫学发病机制，本课题从天人相应的角度出发，拟将自然季节气候因素、机体内分泌免疫功能结合起来，进行文献梳理、流行病学调查、临床检测和动物实验四部分研究。主要通过对四季过敏性鼻炎患者和健康人群的过敏免疫应答相关指标与褪黑素含量的临床检测，探讨人体过敏免疫应答季节性变化的特点及其与自然界光线变化的相关性，再通过动物实验进一步从细胞、分子等水平探索季节气候变化影响过敏性鼻炎的内在机制，同时研究松果腺在季节气候与过敏性鼻炎免疫应答相关性中的地位。本课题从时间医学角度揭示过敏性鼻炎的免疫学发病机制，此研究不仅对深入理解中医"天人相应"理论具有重要的指导意义，也为中西医结合防治过敏性鼻炎的季节性发作提供了理论、流行病学、临床和实验的依据。

Allergic rhinitis is a common clinical allergic disease, the disease occurrence is closely relate with regional, seasonal and climate factors. This characteristic is also mainly related with the body's own immune function disorders. To discuss the immune pathogenesis of allergic rhinitis,this subject includes literature research, epidemiological investigation, clinic research and animal experiment by connecting the change factors of seasonal climate, the regulation of body endorcine immunity with some function. First of all,to discuss the seasonal characteristics of body allergic immunity and the relation between sunshine and body allergic immunity, we will study allergic indexes and melatonin content of allergic rhinitis patients and health people; Then, to explain the mechanism of how seasonal climate influencing on body allergic immunity, we will do animal experiment on cells and molecules levels,at the same time ,we will study on the role of pineal glands play between the seasonal climate and the immune pathogenesis of allergic rhinitis . All these researches will help us to understand the essence of "correspondence between nature and human"from time medicine, at the same time,these can supply some theorical,epidemiological,clinic and experimental evidences of preventing and curing the seasonal allergic rhinitis.