基于可逆Diels-Alder反应构建复杂拓扑链结构以及分子量/序列明确的聚合物

构建各种复杂拓扑结构聚合物以及分子量单分布、序列结构明确的聚合物，对于探索聚合物的链结构与性能的关系并设计具有预定性能的分子结构，有着非常重要的意义。本项目拟基于可逆Diels-Alder“点击”化学反应和可控自由基聚合合成预制单元，进而利用生成的（氧杂环）降冰片烯衍生官能团的开环易位等方法构建大分子复杂拓扑结构聚合物。进一步地，利用可逆Diels-Alder“点击”化学反应合成具有精确分子量和序列结构聚合物。这些结构精致的聚合物将可进一步作为功能性聚合物材料，如自组装为生物医用材料和自愈合聚合物材料。本项目研究将建立合成复杂拓扑结构和精确分子量/序列结构的新策略，开发具有新型拓扑结构的聚合物，拓展和丰富高分子合成方法，为精确研究聚合物结构与性能关系奠定基础。

Toward to deep insight into the structure-property relationship and precisely design predetermined polymer architecture, the construction of polymers with complex topology and molecularly defined/precise sequence is very crucial. This project will use the retro maleimide-furan Diels-Alder reaction and controlled radical polymerization to prepare the building block, and then construct the complex topological polymer with ROMP approach. Moreover, by using the retro Diels-Alder reaction Thiol-ene Michael click reaction, polymers with precise molecular weight and sequence can be fabricated. All these precise polymer can be used as functional polymer, such as self-assembly for biomedical purpose and self-healing polymeric material. This project will develop novel strategy for building up new complex topological polymers and precise polymers, enrich the synthetic methods for well-defined polymer. Eventually, these explorations will lay a solid foundation for the research of structure-property relationship.