基于SphK1/S1P信号通路介导糖尿病肾病机制探讨"肾络癥瘕理论"和消癥散结法干预作用

本课题针对糖尿病肾病，以肾络癥瘕理论为基础，以消癥散结为治疗方法，选用肾炎防衰液为代表方剂，研究肾炎防衰液在延缓糖尿病肾病进程中的作用。我们既往的系列研究已确证肾炎防衰液具有防治慢性肾纤维化的作用。本研究提出假设肾炎防衰液可能通过干预的SphK1/S1P信号转导系统延缓糖尿病肾病的进展，从而更有效的治疗糖尿病肾病，并进一步发展肾络癥瘕病机理论。本研究在此基础上，选用糖尿病肾病动物模型，运用肾炎防衰液进行干预，研究中药延缓糖尿病肾病发展作用机制。创新点：1.提出消癥散结法可以延缓糖尿病肾病进程；2. 以糖尿病肾病为切入点，研究肾络癥瘕理论与Sphk1/S1P信号转导系统调控机制的相关性。

This project adopts the Xiaozheng Sanjie and selects the nephritis Fangshuai fluid to study the effect of nephritis Fangshuai fluid in terms of preventing the diabetic nephropathy. Our previous research has proven that nephritis Fangshuai fluid can preventing the chronic renal fibrosis, so this project assumes that nephritis Fangshuai fluid can delay the diabetic nephropathy by interferencing the SphK1/S1P signal transmission system to further cure the diabetic nephropathy, and develop the Shenluotong Zhengjia pathogenesis theory. .This project selects the Animal models of diabetic nephropathy and adopts the Nephritis and senility fluid intervention to study the effect of traditional Chinese medicine in terms of delaying the development of diabetic nephropathy. Innovation points: (1) propose that Xiaozheng sanjie law can delay the process of diabetic nephropathy; (2) study the relationship between Kidney by Zhengjia theory and Regulation mechanisms of SphK/S1P signal transduction system.