蜈蚣败毒饮在滤泡性辅助性T细胞亚群（Tfh）横纵向交叉通路IL-21/Bcl-6/CXCR5+ICOS和Tfh1/Tfh2/Tfh17中治疗银屑病的机制研究

银屑病是由多因素诱发的疑难性皮肤病，课题组突破以往多从血分辨治的桎梏，从毒、瘀理论入手，重新解释银屑病“毒蕴瘀结”病机，提出“解毒消源，祛瘀截末，辅以防变”的治疗原则和“两极阻断学说”，拟定蜈蚣败毒饮。既往从小鼠模型、表皮细胞及Keratin6、Bcl-2、NF-κB基因表达进行研究，同时针对核心病机T细胞，由Th1/Th2漂移到Th17进行了探索。课题组发现IL-21是联系Tfh与Th17的关键因子，既往研究的Bcl为Tfh的重要激活因子亚型。因此提出“蜈蚣败毒饮可能通过影响滤泡性辅助性T细胞亚群的横纵向通路来调控Th1/Th2/Th17亚群平衡而治疗银屑病”的假说，创新性的将Tfh细胞分为横向IL-21/Bcl-6/CXCR5+ICOS和纵向Tfh1/Tfh2/Tfh17的交叉通路，拟对新型Tfh细胞亚群的刺激、激活、分泌因子进行分析，从而建立蜈蚣败毒饮治疗银屑病的T细胞网络机制体系。

Psoriasis is a difficult skin disease that is induced by multiple factors, the research group breaks through the previous shackles that treatment from the “blood” and starts with the theories of “poison” and “stasis”, we reinterprets the pathogenesis of psoriasis which is “poison containment and stasis accumulation”, puts forward the principle of treatment of “detoxication to eliminate the source, removing stasis to cut the end, adjuvant therapies to prevent changes” and “poles blocking theory”, thus founding the traditional Chinese medicine name “Wugong Baidu Decoction”. Previous studies have been carried out in many ways such as mouse models, epidermal cells and genes expression of Keratin6, Bcl-2, NF-κB, etc, meanwhile, the research group has explored from Th1/Th2 drift to Th17 aiming at the core pathogenesis of T cells. Research group found that IL-21 in a key factor in connection with Tfh and Th17, and Bcl that previously studied is an important activator subtype of Tfh. So proposing the hypothesis of “the mechanism of psoriasis treatment with Wugong Baidu Decoction may be the regulation of balance of Th1/Th2/Th17 subgroup through the transverse and longitudinal pathways of T follicular helper cells”, innovatively, the cross paths are divided into transverse path of IL-21/Bcl-6/CXCR5+ICOS and longitudinal path of Tfh1/Tfh2/Tfh17, the study is intended to analyze the simulating factors, activating factors and secretory factors, thus establishing network mechanism of T cells of psoriasis treatment with Wugong Baidu Decoction.