拟生物体系的物理有机和自由基化学的研究

对与生命科学有关的若干重要化学过程进行物理有机和自由基化学研究，包括：生物抗氧化剂的协同作用和微环境效应；辅酶NADH还原反应机理及生物活性分子的电子转移反应；疏水亲脂作用引起的有机分子的簇集、解簇集和自卷；自由基自旋离域参数σJJ的应用；超分子体系中的光诱导电子转移、能量传递和化学转换；一氧化氮自由基的电子和自由基转移。

Electron transfer，hydrophobic/lipophilic interactions，nitric oxide transfer.and free radical induced peroxidations play important roles in life processes. These.life science-related chemical processes have been studied in mimetic biological.systems by using theories and experimental approaches of physical organic chemistry.and free radical chemistry to evaluate the chemical basis of their physiological.functions. Important progress has been obtained in the following fields: (1) Reduction.mechanism of co-enzyme NADH and electron transfer reactions of biologically active.molecules; (2) Aggregation, deaggregation and self-coiling of organic molecules.induced by hydrophobic/lipophilic interactions and application of free radical spin.delocalization parameter σ..JJ; (3) photoinduced electron transfer, energy transfer and.chemical transformation in supramolecular systems; (4) Electron transfer and free.radical transfer of nitric oxide; (5) Synergistic and microenvironmental effects of.bio-antioxidants.