Fe/Cu/Mn簇基配合物型Fenton催化剂的可控组装及化学动力学抗肿瘤治疗应用探索

癌症是全球人类死亡的重要原因之一。近年来基于肿瘤微环境发展的化学动力学治疗（CDT）策略不同于光动力学治疗(PDT)及声动力学治疗(SDT)等，其无需外加能量供应而将肿瘤内H2O2通过芬顿、类芬顿反应转变为活性氧物种（ROS），能持续有效的消除肿瘤，吸引了科学家们的广泛关注。但考虑到肿瘤组织弱酸性的微环境条件及内源性H2O2不足等，目前芬顿、类芬顿反应催化效率仍受到很大的限制，CDT策略还难以达到理想的治疗效果。基于此，本项目拟设计合成系列具有精准结构的Fe/Mn/Cu等簇基金属配合物，利用它们作为芬顿、类芬顿反应催化剂，开展CDT抗肿瘤治疗应用研究。并利用质谱技术开展具有CDT应用前景的簇基配合物的溶液结构特征及可控组装研究。具有精准结构特征的芬顿、类芬顿反应分子型催化剂的结构设计及CDT功能开发，有利于明确其构效关系及调控机制，从而为新型高效CDT药物开发提供依据。

Cancer is one of the most important causes of human death in the world. Different from photodynamic therapy (PDT) and sonodynamic therapy (SDT), the development of chemodynamic therapy (CDT) strategy, based on tumor microenvironment, which can transform intratumoral H2O2 into reactive oxygen species (ROS), through Fenton/Fenton-like reaction, with on need of exogenous energy supply was explored to eliminate tumor, attract extensive attention from scientists in recent years. However, the catalytic efficiency of Fenton/Fenton-like reactions has been restricted by the insufficiently endogenous H2O2 and the weak acid conditions within the tumor microenvironment, and the CDT strategy is still difficult to take desired effect. This project intends to design and synthesize a series of Fe/Mn/Cu cluster-based complexes with precise structural characteristics. Using them as catalysts for Fenton/Fenton-like reaction, CDT anti-tumor strategy will be carried out. Mass spectrometry was used to study the solution structural characteristics and controlled assembly of cluster-based complexes with CDT applications. The structure design and CDT function development of molecular catalyst with precise structure for Fenton/Fenton-like reaction, are conducive to clarifying their structure-activity relationship and regulatory mechanism, thus providing a basis for the development of new CDT drugs.