复发性抑郁缓解者情绪表象加工损害的神经机制及积极表象干预研究

表象加工能力在情绪失调与认知行为偏差之间扮演着重要的角色。情绪表象加工损害使得抑郁者在缓解期内难以摆脱消极信息对认知和行为的影响，从而增加抑郁症复发的危险。为延长抑郁缓解时间，减少抑郁症的复发率，本研究采用事件相关电位和近红外光学脑成像技术，从抑郁缓解者情绪表象生成能力、转换能力和操纵能力三个方面去考查抑郁缓解组、抑郁组和对照组在情绪表象加工能力的神经电活动及血氧代谢活动的差异，系统深入地阐明复发性抑郁缓解者情绪表象加工能力损害的神经机制。在此基础上，利用表象训练可以精准化地针对抑郁症状制定干预策略的优点，研究进一步探究了积极表象生成、转换和操纵训练对抑郁缓解者认知行为偏差的实验干预效果。研究从情绪表象、临床情感障碍和脑神经科学交叉领域的角度出发，从新的视角探讨复发性抑郁个体在缓解期情绪表象加工损害的神经机制及干预效果，拓展了抑郁情绪表象的研究领域。

Imagery processing ability plays an important role in the relationship between emotional disorders and cognitive behavioral biases. The impairment of emotional imagery makes it difficult for depressive patients to get rid of the impact of negative information on cognition and behavior in remission phase, and increases the risk of recurrence of depression.In order to prolong the remission time of depression and reduce the recurrence rate of depression, the study examined the differences of neuroelectric activity and blood oxygen metabolism activity among the depression remission group, depression group and control group in terms of the ability of imagery generation and of imagery transference and of imagery manipulation with the method of event-related potentials and functional near-infrared spectroscopy. The study systematically clarifies the damage mechanism of emotional imagery processing in the patients remitted from recurrent depression.With the advantage that imagery training can accurately formulate intervention strategies for depressive symptoms, the study further explored the experimental intervention effect of positive imagery generation，conversion and manipulation on cognitive behavior bias of depression relievers. From the perspective of inter-discipline area of emotion imagery,clinical affective disorder and brain neuroscience, the study explores the emotion imagery damage mechanism and the experimental intervention effect of recurrent depressive individuals in remission phase, and expands the research areas of emotion imagery in depression.