拓扑结构为acs的三核Eu-MOF的合成、柔性研究及生物检测性能研究

灵敏度和稳定性是衡量生物检测材料的关键性能指标。稀土金属有机框架（Ln-MOF）的高比表面积有利于提升材料的灵敏度，但是其空旷易坍塌的结构会降低材料和检测的稳定性。本项目拟构筑具有柔性框架的Eu-MOF材料，使其在特定客体分子的吸附及脱附过程中，通过孔道的自适性变化实现比表面积的增大与减小，使MOF兼具高检测灵敏度与高稳定性。拟选取具有一定柔性特性的拓扑结构acs为研究模型，系统开展拓扑结构为acs的三核Eu-MOF的合成、框架柔性研究及生物传感性能研究，考察客体分子及所用配体的结构特性对Eu-MOF框架柔性特性的影响规律，使用X射线衍射手段分析材料在客体吸脱附过程中的动态结构变化，优化柔性Eu-MOF的构筑条件并获得Eu-MOF骨架的柔性调控规律；探究所得材料的生物检测性能及机理，分析材料骨架的柔性对检测性能的影响规律，为开发综合性能良好的生物检测材料提供新的研究思路及研究经验。

Sensitivity and stability are the key performance indexes to the bio-sensors. Constructing Ln-MOFs with high surface area can enhance the sensitivity effectively. However, they usually suffer from the poor stability. In order to improve the sensitivity without losing the stability, we propose to build the flexible Eu-MOFs. Their dynamic structures can expand and shrink during the adsorption and desorption of the guest molecules. In this project, the Eu-MOFs with the acs topology is chosen as the model MOFs. Through the systematic experiments and characterizations, we expect to obtain the influences of the guest molecules and the organic ligands to the pore properties and the flexibility of the Eu-MOFs. With the help of X-ray diffraction, their dynamic structures during the adsorption and desorption processes will be thoroughly analyzed. Further, the optimized synthesis conditions and the influences of the flexibility of the Eu-MOFs will be summarized. Besides, the flexible Eu-MOFs will be explored in biosensing. Through the analysis of the sensing performance and the mechanism, the relationships between the flexibility and the sensitivity will be studied. Based on the above researches, we will provide a unique way to consturct Eu-MOFs with high sensitivity and stability, which is of great significance to promote the sensing performance of Eu-MOFs as the biosensors.