Pyroptosis, a New Breakthrough in Cancer Treatment.

Pyroptosis, a New Breakthrough in Cancer Treatment.
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焦亡,癌症治疗的新突破

DOI:
10.3389/fonc.2021.698811
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发表时间:
2021
影响因子:
4.7
通讯作者:
Zhou S
Zhou S
中科院分区:
医学3区
文献类型:
--
作者:
Wu D;Wei C;Li Y;Yang X;Zhou S

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细胞死亡的方式大致可分为两类:细胞坏死和PCD(程序性细胞死亡)。Pyroptosis是一种PCD,其发生依赖于gasdermin蛋白家族,并会产生炎症反应。近年来,随着研究的不断深入,越来越多的证据表明,细胞凋亡与肿瘤的发生、发展密切相关。肿瘤的治疗是一个世界性的大问题。我们关注的是能否从机理上发现新的潜在肿瘤标志物和新的治疗靶点。如果能了解肿瘤细胞凋亡的机制,明确肿瘤细胞凋亡与肿瘤发生发展的关系,将为临床肿瘤治疗提供新的参考。
The way of cell death can be roughly divided into two categories: cell necrosis and PCD(programmed cell death). Pyroptosis is a kind of PCD, its occurrence depends on the gasdermin protein family and it will produce inflammatory response. With constant research in recent years, more and more evidences show that pyroptosis is closely related to the occurrence and development of tumors. The treatment of tumors is a big problem worldwide. We focus on whether we can discover new potential tumor markers and new therapeutic targets from the mechanism. If we can understand the mechanism of pyroptosis and clear the relationship between pyroptosis and the development of tumors, this may provide a new reference for clinical cancer treatment.
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发表时间: 2010-03-01
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