Salivary cortisol and prefrontal cortical thickness in middle-aged men: A twin study.
Salivary cortisol and prefrontal cortical thickness in middle-aged men: A twin study.
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DOI：
10.1016/j.neuroimage.2010.02.026
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发表时间：
2010-11-15
期刊：
影响因子：
5.7
通讯作者：
Franz, Carol E.
中科院分区：
文献类型：
--
作者：
Kremen, William S.;O'Brien, Robert C.;Panizzon, Matthew S.;Prom-Wormley, Elizabeth;Eaves, Lindon J.;Eisen, Seth A.;Eyler, Lisa T.;Hauger, Richard L.;Fennema-Notestine, Christine;Fischl, Bruce;Grant, Michael D.;Hellhammer, Dirk H.;Jak, Amy J.;Jacobson, Kristen C.;Jernigan, Terry L.;Lupien, Sonia J.;Lyons, Michael J.;Mendoza, Sally P.;Neale, Michael C.;Seidman, Larry J.;Thermenos, Heidi W.;Tsuang, Ming T.;Dale, Anders M.;Franz, Carol E.
尽管糖皮质激素受体在前额皮质中高度表达，但海马体仍然是研究皮质醇和大脑之间关系的文献中的主要焦点。我们在 388 名 51-59 岁中年男性双胞胎样本中检查了皮质醇水平与前额叶和前扣带皮层区域厚度以及海马体积的表型和遗传关联。在皮质醇水平与左背外侧（额上回、左喙中额回）和腹外侧（岛盖部、三角部、眼眶部）前额叶区域、右背外侧（额上回）和内侧眶额皮质的厚度之间发现了小但显着的负表型关联。在调整一般认知能力、心血管危险因素和抑郁因素后，大多数关联仍然显着。双变量遗传分析表明，某些关联主要是由共同的遗传影响造成的。也就是说，一些导致皮质醇水平升高的基因也往往会导致前额皮质厚度减少。衰老与下丘脑-垂体-肾上腺功能效率降低、额叶萎缩以及健康问题增加有关，但我们目前的数据不允许我们确定影响的方向。此外，观察到的关联的程度或方向以及它们共享的遗传基础的程度很可能随着这些个体的年龄而改变。正在进行纵向评估，以阐明皮质醇和大脑形态变化的纵向表型的关联方向和遗传基础。
Although glucocorticoid receptors are highly expressed in the prefrontal cortex, the hippocampus remains the predominant focus in the literature examining relationships between cortisol and brain. We examined phenotypic and genetic associations of cortisol levels with the thickness of prefrontal and anterior cingulate cortex regions, and with hippocampal volume in a sample of 388 middle-aged male twins who were 51–59 years old. Small but significant negative phenotypic associations were found between cortisol levels and the thickness of left dorsolateral (superior frontal gyrus, left rostral middle frontal gyrus) and ventrolateral (pars opercularis, pars triangularis, pars orbitalis) prefrontal regions, and right dorsolateral (superior frontal gyrus) and medial orbital frontal cortex. Most of the associations remained significant after adjusting for general cognitive ability, cardiovascular risk factors, and depression. Bivariate genetic analyses suggested that some of the associations were primarily accounted for by shared genetic influences; that is, some of the genes that tend to result in increased cortisol levels also tend to result in reduced prefrontal cortical thickness. Aging has been associated with reduced efficiency of hypothalamic-pituitary-adrenal function, with frontal lobe shrinkage, and with increases in health problems, but our present data do not allow us to determine the direction of effects. Moreover, the degree or the direction of the observed associations and the extent of their shared genetic underpinnings may well change as these individuals age. Longitudinal assessments are underway to elucidate the direction of the associations and the genetic underpinnings of longitudinal phenotypes for changes in cortisol and brain morphology.
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影响因子：
5.7
作者：
Fischl, B;Sereno, MI;Dale, AM
通讯作者：
Dale, AM
影响因子：
3
作者：
Hauger, Richard L.;Risbrough, Victoria;Dautzenberg, Frank M.
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Dautzenberg, Frank M.
影响因子：
5.7
作者：
Dale, AM;Fischl, B;Sereno, MI
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Sereno, MI
影响因子：
5.7
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