ERK phosphorylates chromosomal axis component HORMA domain protein HTP-1 to regulate oocyte numbers.
ERK phosphorylates chromosomal axis component HORMA domain protein HTP-1 to regulate oocyte numbers.
复制标题
DOI：
10.1126/sciadv.abc5580
复制
发表时间：
2020-10
期刊：
影响因子：
13.6
通讯作者：
Arur S
中科院分区：
文献类型：
--
作者：
Das D;Chen SY;Arur S
ERK phosphorylates meiosis component HTP-1 to regulate oocyte numbers. Oocyte numbers, a critical determinant of female reproductive fitness, are highly regulated, yet the mechanisms underlying this regulation remain largely undefined. In the Caenorhabditis elegans gonad, RAS/extracellular signal–regulated kinase (ERK) signaling regulates oocyte numbers; mechanisms are unknown. We show that the RAS/ERK pathway phosphorylates meiotic chromosome axis protein HTP-1 at serine-325 to control chromosome dynamics and regulate oocyte number. Phosphorylated HTP-1(S325) accumulates in vivo in an ERK-dependent manner in early-mid pachytene stage germ cells and is necessary for synaptonemal complex extension and/or maintenance. Lack of HTP-1 phosphorylation leads to asynapsis and persistence of meiotic double-strand breaks, causing delayed meiotic progression and reduced oocyte number. In contrast, early onset of ERK activation causes precocious meiotic progression, resulting in increased oocyte number, which is reversed by removal of HTP-1 phosphorylation. The RAS/ERK/HTP-1 signaling cascade thus functions to monitor formation and maintenance of synapsis for timely resolution of double-strand breaks, oocyte production, and reproductive fitness.
登录
查看更多内容
细胞外调节的激酶：从RAS到ERK底物的信号传导以控制生物学结果。
影响因子：
--
作者：
Eblen ST
通讯作者：
Eblen ST
DOI：
10.1126/science.1171396
发表时间：
2009-05-15
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Fan HY;Liu Z;Shimada M;Sterneck E;Johnson PF;Hedrick SM;Richards JS
通讯作者：
Richards JS
影响因子：
11.8
作者：
Arur, Swathi;Ohmachi, Mitsue;Berkseth, Matt;Nayak, Sudhir;Hansen, David;Zarkower, David;Schedl, Tim
通讯作者：
Schedl, Tim
影响因子：
4
作者：
De Felici, M;Klinger, FG;Lobascio, M
通讯作者：
Lobascio, M
影响因子：
11.8
作者：
Drake, Melanie;Furuta, Tokiko;Suen, Kin Man;Gonzalez, Gabriel;Liu, Bin;Kalia, Awdhesh;Ladbury, John E.;Fire, Andrew Z.;Skeath, James B.;Arur, Swathi
通讯作者：
Arur, Swathi