Extracellular-Regulated Kinases: Signaling From Ras to ERK Substrates to Control Biological Outcomes.
Extracellular-Regulated Kinases: Signaling From Ras to ERK Substrates to Control Biological Outcomes.
复制标题
细胞外调节的激酶：从RAS到ERK底物的信号传导以控制生物学结果。
DOI：
10.1016/bs.acr.2018.02.004
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发表时间：
2018
影响因子：
--
通讯作者：
Eblen ST
中科院分区：
文献类型：
--
作者：
Eblen ST
细胞外调节激酶ERK 1和ERK 2是进化上保守的、普遍存在的丝氨酸-苏氨酸激酶，其参与调节正常和病理条件下的细胞信号传导。它们的表达对于发展至关重要，并且它们的过度活化是癌症发展和进展的主要因素。自从它们被发现作为由有丝分裂原和Ras突变激活的主要信号介质之一以来，我们已经了解了很多关于它们的调节，包括它们的激活、结合伴侣和底物。在这篇综述中，我将讨论一些已经发现的关于Ras到ERK通路的成员，包括通过生长因子和细胞粘附通路调节其活化。展望ERK激活的下游，我还将强调一些已经发现的许多ERK底物，包括那些参与反馈调节，细胞迁移和细胞周期进程，通过控制转录，前mRNA剪接和蛋白质合成。
The extracellular regulated kinases ERK1 and ERK2 are evolutionarily conserved, ubiquitous serine-threonine kinases that are involved in regulating cellular signaling in both normal and pathological conditions. Their expression is critical for development and their hyperactivation is a major factor in cancer development and progression. Since their discovery as one of the major signaling mediators activated by mitogens and Ras mutation, we have learned much about their regulation, including their activation, binding partners and substrates. In this review, I will discuss some of what has been discovered about the members of the Ras to ERK pathway, including regulation of their activation by growth factors and cell adhesion pathways. Looking downstream of ERK activation, I will also highlight some of the many ERK substrates that have been discovered, including those involved in feedback regulation, cell migration, and cell cycle progression through the control of transcription, pre-mRNA splicing and protein synthesis.
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影响因子：
3.5
作者：
BRUNET, A;PAGES, G;POUYSSEGUR, J
通讯作者：
POUYSSEGUR, J
DOI：
10.1083/jcb.148.5.849
发表时间：
2000-03-06
期刊：
The Journal of cell biology
影响因子：
--
作者：
Adachi M;Fukuda M;Nishida E
通讯作者：
Nishida E
影响因子：
13.8
作者：
Bryant, Kirsten L.;Mancias, Joseph D.;Kimmelman, Alec C.;Der, Channing J.
通讯作者：
Der, Channing J.
影响因子：
2.9
作者：
BOULTON, TG;GREGORY, JS;COBB, MH
通讯作者：
COBB, MH
影响因子：
7.3
作者：
Ardighieri, Laura;Zeppernick, Felix;Hannibal, Charlotte G.;Vang, Russell;Cope, Leslie;Junge, Jette;Kjaer, Susanne K.;Kurman, Robert J.;Shih, Ie-Ming
通讯作者：
Shih, Ie-Ming