Model Study of Vector-Loop Morphology During Electrical Mapping of Microscopic Conduction in Cardiac Tissue
Model Study of Vector-Loop Morphology During Electrical Mapping of Microscopic Conduction in Cardiac Tissue
复制标题
心脏组织微观传导电测绘过程中矢量环形态的模型研究
DOI：
--
复制
发表时间：
2001
期刊：
影响因子：
--
通讯作者：
E. Hofer
中科院分区：
文献类型：
--
作者：
G. Plank;E. Hofer
心脏表面电位差的环形态变化很大，一般认为是由于组织结构的不连续性。这项工作的目的是检查，如果实验发现的电场E的矢量环的多样性也可能出现在连续各向异性传导。为此，使用了单域计算机模型，包括一个二维的可兴奋的组织片包围着一个无界的体积导体。在组织表面附近，我们的计算预测了Φe的窄双相过程，峰-峰分离小于400 μm。我们研究了如何准确地E可以重建从四元件电极阵列记录的测量和激活序列，电极间的间距，和探针的方向如何影响结果。我们发现“封闭”的矢量环E在平面，并在椭圆波阵面的顶点，而在这些区域之外的矢量环是“开放的”。不同的探针方向和大小导致矢量环形态的实质性变化。我们得出结论，在心脏电流源附近，E的准确测量需要电极间距离小于100 μm。© 2000生物医学工程学会。
PAC00：8719Nn，8719Hh
AbstractThe large variety in loop morphology of potential differences recorded at the cardiac surface has been generally attributed to structural discontinuities of the tissue. The aim of this work was to examine if the diversity of vector loops of the electric field E found experimentally may also arise during continuous anisotrope conduction. For this purpose a monodomain computer model was used, consisting of a two-dimensional sheet of excitable tissue surrounded with an unbounded volume conductor. Close to the tissue surface our computations predicted a narrow biphasic course of Φe with peak-to-peak separation of less than 400 μm. We examined how accurately E could be reconstructed from measurements recorded with four-element electrode arrays and how activation sequence, interelectrode spacing, and probe orientation affects the results. We found “closed” vector loops of E in planar, and at the apex of elliptical wave fronts, whereas outside of these regions vector loops were “open.” Varying probe orientation and size resulted in substantial changes of vector-loop morphology. We concluded that close to the cardiac current sources accurate measurement of E would require interelectrode distances of less than 100 μm. © 2000 Biomedical Engineering Society.
PAC00: 8719Nn, 8719Hh
登录
查看更多内容
影响因子：
20.1
作者：
LUO, CH;RUDY, Y
通讯作者：
RUDY, Y
心脏跨膜电流的体内估计。
影响因子：
20.1
作者：
Witkowski,FX;Kavanagh,KM;Penkoske,PA;Plonsey,R
通讯作者：
Plonsey,R
心肌传导阻滞的识别：犬心外膜的体外观察。
影响因子：
10.8
作者：
Kadish,A;Spear,J
通讯作者：
Spear,J
影响因子：
20.1
作者：
Arisi,G;Macchi,E;Corradi,C;Lux,RL;Taccardi,B
通讯作者：
Taccardi,B
使用薄膜传感器在微观尺寸范围内测量心脏的激活模式。
DOI：
10.1152/ajpheart.1994.266.5.h2136
发表时间：
1994
期刊：
The American journal of physiology
影响因子：
--
作者：
Hofer,E;Urban,G;Spach,MS;Schafferhofer,I;Mohr,G;Platzer,D
通讯作者：
Platzer,D